The objective of this study was to evaluate the feasibility of replacing or supplementing conventional bubble sparging for cell culture aeration with bubble-free gas transfer using a silicone membrane gas exchanger.
This study also establishes practical start-up and operating guidelines for implementing bubble-free membrane gas transfer in mammalian cell culture bioreactors. Collectively, the findings demonstrate the potential of membrane-based, bubble-free gas transfer as an alternative aeration strategy for upstream bioprocessing.
The white paper can be downloaded here: Bubble-Free Membrane Aeration in Mammalian Cell Culture Bioreactors: An Alternative to Conventional Bubble Sparging
